aGVHD grading calculator

Calculate data-driven and conventional grades for acute graft-versus-host disease.

Organ stages

Select one stage for each organ.

0 of 3 selected

Skin

0 1 2 3 4

Liver

0 1 2 3 4

Gastrointestinal

0 1 2 3 4

Grading results

PC1, 12 grades Data-driven scale: —
PC1, 6 grades Simplified scale: —
PC1, 4 grades Further simplified scale: —
MAGIC Conventional grade, one gastrointestinal stage: —

Select all three stages to calculate.

For research use only. This calculator has not been validated for clinical use.

Computational HematologyaGVHD research calculator

Study notes

Inputs and grades

Select skin, liver, and gastrointestinal stages from 0 to 4. PC1 reports the data-driven grade on three scales, with 12, 6, and 4 grades. The MAGIC result uses a single gastrointestinal stage. A dash means a result is pending. When all three organs are at stage 0, all four grades are 0.

Study cohort

The grading models were developed using data from 3,019 patients who developed aGVHD after allogeneic hematopoietic stem cell transplantation. Five German transplant centers contributed data: Berlin, Essen, Hamburg, Hannover, and Heidelberg.

The researchers compared the data-driven models with conventional grading and evaluated them using independent center data.

Study limitations

The algorithm has not been prospectively validated. Treatment options were not randomized. By using the calculator, you confirm that you understand these research limitations.

Read the published study ↗